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Darol Dodd, Gabrielle Willson, Horace Parkinson and Edilberto Bermudez Two-year drinking water carcinogenicity study of methyl tertiary-butyl ether (MTBE) in Wistar rats Journal of Applied Toxicology 33

Version of Record online: 7 DEC 2011 | DOI: 10.1002/jat.1776

Exposure of Wistar rats to MTBE in the drinking water for two years resulted in minimal exposure-related effects, including increased kidney weights. Chronic progressive nephropathy was evident in male and female rats and was exacerbated by exposure to MTBE. Brain astrocytomas were present but were not statistically significantly different from concurrent controls and fell within historical control ranges. Furthermore, the brain has not been identified as a target organ in previous chronic studies with MTBE or related compounds.

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