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Pietro Maria Chagas, Cristiani Folharini Bortolatto, Ethel Antunes Wilhelm and Cristina Wayne Nogueira High doses of 2,2′-dithienyl diselenide cause systemic toxicity in rats: an in vitro and in vivo study Journal of Applied Toxicology 33

Version of Record online: 19 DEC 2011 | DOI: 10.1002/jat.1777

Introduction: The potential toxicity of DTDS has not been studied. Material and Methods: Effect of DTDS on sulfhydryl enzymes activities was investigated in vitro and single oral doses were administered in rats. Results: DTDS inhibited δ-ALA-D and Na+–K+-ATPase activities, these effects were restored by DTT, and elicited thiol oxidase-like activity. In vivo, DTDS caused systemic toxicity. Discussion: Interaction with cisteinyl residues seems to mediate the inhibitory effects in vitro. Moreover, high oral doses of DTDS induced toxicity in rats.

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