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Yong-Jun Shin, Joo Hyun Lee, Ju-Hee Oh and Young-Joo Lee Low-dose probenecid selectively inhibits urinary excretion of phenolsulfonphthalein in rats without affecting biliary excretion Journal of Applied Toxicology 33

Version of Record online: 7 DEC 2011 | DOI: 10.1002/jat.1778

The optimal dosage range of probenecid that can selectively inhibit urinary excretion of anionic compounds in rats without inhibition of biliary excretion was determined. Treatment with 100, 200 or 400mgkg−1 probenecid decreased both CLr and CLb of PSP, whereas 2 and 10 mgkg−1 decreased only CLr. The ED50 of probenecid for inhibiting CLr and CLb were 0.925 and 23.9mgkg−1, respectively. A low dose of probenecid selectively inhibits urinary excretion of PSP without affecting biliary excretion.

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