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Roberto Heredia-Ortiz, Aurélie Berthet and Michèle Bouchard Toxicokinetic modeling of folpet fungicide and its ring-biomarkers of exposure in humans Journal of Applied Toxicology 33

Article first published online: 19 DEC 2011 | DOI: 10.1002/jat.1782

A human in vivo toxicokinetic model was built to allow a better understanding of the toxicokinetics of folpet fungicide and its key biomarkers of exposure, and to simulate the transformation of folpet into phthalimide and other ring-metabolites: phthalamic and phthalic acids. The model closely reproduced the time courses of phthalimide in blood and urine as well as total ring-metabolites in urine of five volunteers administered orally 1 mg kg−1 and dermally 10 mg kg−1 of folpet.

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