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Eun Mi Choi Deoxyactein Isolated from Cimicifuga racemosa protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity Journal of Applied Toxicology 33

Version of Record online: 19 DEC 2011 | DOI: 10.1002/jat.1784

Deoxyactein is one of the major constituents isolated from Cimicifuga racemosa. In the present study, we investigated the protective effects of deoxyactein on antimycin A induced toxicity in osteoblastic MC3T3-E1 cells. Pretreatment with deoxyactein prior to antimycin A exposure significantly reduced antimycin A-induced cell damage by preventing mitochondrial membrane potential dissipation, complex IV inactivation, ATP loss, [Ca2+]i elevation, and oxidative stress. Moreover, deoxyactein increased the activation of PI3K, Akt, and CREB inhibited by antimycin A.

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