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L. Barr, G. Metaxas, C. A. J. Harbach, L. A. Savoy and P. D. Darbre Measurement of paraben concentrations in human breast tissue at serial locations across the breast from axilla to sternum Journal of Applied Toxicology 32

Article first published online: 12 JAN 2012 | DOI: 10.1002/jat.1786

The concentrations of five esters of p-hydroxybenzoic acid (parabens) were measured using HPLC-MS/MS at four serial locations across the human breast from axilla to sternum using human breast tissue collected from 40 mastectomies for primary breast cancer in England between 2005 and 2008. One or more paraben esters were quantifiable in 158/160 (99%) of the tissue samples and in 96/160 (60%) all five esters were measured. The overall median value for total paraben was 85.5 ng g−1 tissue (range 0–5134.5).

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