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Mostafa I. Waly, Badreldin H. Ali, Intisar Al-Lawati and Abderrahim Nemmar Protective effects of emodin against cisplatin-induced oxidative stress in cultured human kidney (HEK 293) cells Journal of Applied Toxicology 33

Version of Record online: 23 JAN 2012 | DOI: 10.1002/jat.1788

Cisplatin inhibited antioxidant enzymes (GST, GPx, GR, SOD and CAT) to a level that is significantly lower than the control group. Meanwhile treatment of cells with cisplatin in the presence of emodin significantly ameliorated the inhibited antioxidant enzymes. Controls contained all the reaction reagents except emodin or cisplatin.

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