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Wanida Sukketsiri, Sureerut Porntadavity, Laddawal Phivthong-ngam and Somsong Lawanprasert Lead inhibits paraoxonase 2 but not paraoxonase 1 activity in human hepatoma HepG2 cells Journal of Applied Toxicology 33

Version of Record online: 23 JAN 2012 | DOI: 10.1002/jat.1789

Lead-induced liver damage and malfunction are partly due to a disturbance of the cellular antioxidant balance. Paraoxonase 1 (PON1) and PON2 are highly expressed in the liver and have been proposed as antioxidative enzymes. The effects of lead on PON1 and PON2 activities were investigated in human hepatoma HepG2 cells. Lead reduced PON2, but not PON1, activity and that this reduction was reversed by calcium. Lead-induced oxidative stress and decreased PON2 activity lead to the upregulation of PON2 transcript.

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