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Yuki Ogawa, Masahiro Itoh, Shuichi Hirai, Shigeru Suna, Munekazu Naito, Ning Qu, Hayato Terayama, Ayumi Ikeda, Hidenobu Miyaso, Yoshiharu Matsuno, Masatoshi Komiyama and Chisato Mori Cadmium exposure increases susceptibility to testicular autoimmunity in mice Journal of Applied Toxicology 33

Version of Record online: 23 JAN 2012 | DOI: 10.1002/jat.2713

We investigated the morphological and functional changes of testes in mice treated with a low dose of cadmium chloride (3mg CdCl2/kg body weight) and also examined its toxicity as to susceptibility to EAO testicular autoimmunity. The results showed that exposure to 3 mg CdCl2/kg body weight did not affect the spermatogenic state. However, the blood-testis barrier BTB at the tubuli recti and the rete testis, but not the seminiferous tubules, was slightly weakened, and intra-testicular mRNA expression of interleukin (IL)-6, tumor necrosis factor-α and IL-1β was significantly increased by the CdCl2 treatment. Furthermore, immunization with testicular antigens after the CdCl2 exposure significantly augmented the EAO severity. Therefore, exposure to a low dose of CdCl2 induces no significant disturbance of spermatogenesis, however, it does the CdCl2 treatment change the immunological microcircumstances in the testis, resulting in increased susceptibility to testicular autoimmunity.

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