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Wenchang Zhang, Lei Huang, Cancan Kong, Jin Liu, Lingfeng Luo and Huiling Huang Apoptosis of rat ovarian granulosa cells by 2,5-hexanedione in vitro and its relevant gene expression Journal of Applied Toxicology 33

Version of Record online: 15 FEB 2012 | DOI: 10.1002/jat.2714

Although n-hexane is toxic to the ovary, the related mechanism remains unknown. Apoptosis of rat ovarian granulosa cells is thought to be one of the important reasons for ovarian toxicity. Rat ovarian granulosa cells were exposed in vitro to different concentrations of 2,5-hexanedione (HD, a major metabolite of n-hexane; 0, 20, 40 and 60 mmol l−1) to observe the apoptosis, and its relevant gene expression was investigated. It was found by MTT assay that different exposure doses and different exposure time could inhibit the viability of ovarian granulosa cells.

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