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Petr Mikeš, Václav Šístek, Jan Krouželka, Antonín Králík, Emil Frantík, Jaroslav Mráz and Igor Linhart 3-(3,4-Dihydroxyphenyl)adenine, a urinary DNA adduct formed in mice exposed to high concentrations of benzene Journal of Applied Toxicology 33

Article first published online: 15 FEB 2012 | DOI: 10.1002/jat.2716

Low concentrations of 7-(3,4-dihydroxyphenyl)guanine and 3-(3,4-dihydroxyphenyl)adenine (DHPA), an easily depurinating DNA adduct derived from 1,2-benzoquinone, was detected in the urine of mice repeatedly exposed to benzene vapours at 1800 mg m−3, 6 h per day. It was found in eight out of total 30 urine samples at concentrations of 352 ± 146 pg ml−1. Conversion of benzene to DHPA was estimated to 2.2 × 10−6 % of the absorbed dose. Search for the other five nucleobase adducts derived from benzene was negative.

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