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Patricia Kaaijk, Arno A. J. van der Ark, Geert van Amerongen and Germie P. J. M. van den Dobbelsteen Nonclinical vaccine safety evaluation: advantages of continuous temperature monitoring using abdominally implanted data loggers Journal of Applied Toxicology 33

Version of Record online: 8 MAR 2012 | DOI: 10.1002/jat.2720

Fever has been reported as the most common adverse event after vaccination in infants and children. For this reason it is important that prior to clinical testing of a new vaccine, change in body temperature following vaccination is tested carefully in nonclinical animal studies. In the present study implanted temperature loggers were successfully used to define an adequate fixed time point to be applied in determining rectal body temperature in a formal GLP toxicology study with a new vaccine candidate.

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