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Mohamed A. Hammad, Mohamed Sadek Abdel-Bakky, Larry A. Walker and Mohammad K. Ashfaq Tissue factor antisense deoxyoligonucleotide prevents monocrotaline/LPS hepatotoxicity in mice Journal of Applied Toxicology 33

Version of Record online: 9 MAR 2012 | DOI: 10.1002/jat.2728

Tissue factor (TF) is a membranous glycoprotein that functions as a receptor for coagulation factor VII/VIIa and activates the coagulation system when blood vessels or tissues are damaged. TF was upregulated in our monocrotaline (MCT)/lipopolysaccharide (LPS) hepatotoxicity model. We tested the hypothesis that TF-dependent fibrin deposition and lipid peroxidation in the form of oxidized low-density-lipoprotein (ox-LDL) accumulation contribute to liver inflammation induced by MCT/LPS in mice. In the present study, we blocked TF using antisense oligodeoxynucleotides against mouse TF (TF-ASO).

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