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Ramachandra S. Naik, Weiyi Liu and Ashima Saxena Development and validation of a simple assay for the determination of cholinesterase activity in whole blood of laboratory animals Journal of Applied Toxicology 33

Version of Record online: 12 MAR 2012 | DOI: 10.1002/jat.2730

The goal of this study was to develop and validate a simple assay for measuring acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities in whole blood from humans as well as experimental animals. AChE activity was determined by measuring the hydrolysis of acetylthiocholine in the presence of 20 µ m ethopropazine and BChE activity was determined by measuring the hydrolysis of butyrylthiocholine in the absence of an inhibitor. The method was validated for blood from several animal species, including rodents and nonhuman primates.

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