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Darol E. Dodd, Linda J. Pluta, Mark A. Sochaski, Deborah A. Banas and Russell S. Thomas Subchronic hepatotoxicity evaluation of bromobenzene in Fischer 344 rats Journal of Applied Toxicology 33

Article first published online: 9 MAR 2012 | DOI: 10.1002/jat.2732

Male Fischer 344 rats were administered bromobenzene by gavage at 0, 25, 100, 200, 300, or 400 mg kg−1 per day for 5 days and 2, 4 and 13 weeks. Mean body weight decreased 5-10% at 400 mg kg−1 per day. Liver weight increases were dose- and exposure time-related and significant at ≥25 mg kg−1 per day. Incidence and severity of centrilobular cytoplasmic alteration and hepatocyte hypertrophy were also related to dose and exposure time. A NOAEL of 200 mg kg−1 per day was selected based on a statistically significant increase in hypertrophy at ≥400 mg kg−1 per day.

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