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Malgorzata M. Brzóska, Malgorzata Galażyn-Sidorczuk and Ilona Dzwilewska Ethanol consumption modifies the body turnover of cadmium: a study in a rat model of human exposure Journal of Applied Toxicology 33

Version of Record online: 8 MAR 2012 | DOI: 10.1002/jat.2734

The impact of ethanol on the body turnover of cadmium in a rat model reflecting excessive alcohol consumption in humans chronically exposed to moderate and relatively high levels of this heavy metal was studied. The results provide strong evidence that ethanol consumption under long-term moderate and relatively high exposure to cadmium modifies its metabolism in the organism, resulting in lower body burden of this toxic metal. Based on the findings, it can be concluded that cadmium concentration in the blood and tissues of alcohol abusers chronically exposed to moderate and relatively high levels of this metal may be lower, whereas its urinary excretion is higher than in their non-drinking counterparts. However, since ethanol is toxic itself, the decreased body burden of cadmium owing to alcohol consumption does not allow for the conclusion that the risk of health damage may be lower with co-exposure to these xenobiotics. In further study, it will be investigated how the ethanol-induced changes in the body status of cadmium influence the effects of its toxic action.

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