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Wei Ji, Hualei Liang, Wenshan Zhou and Xuezhen Zhang Apoptotic responses of zebrafish (Danio rerio) after exposure with microcystin-LR under different ambient temperatures Journal of Applied Toxicology 33

Article first published online: 9 MAR 2012 | DOI: 10.1002/jat.2735

Microcystins (MCs) can cause evident hepatic apoptosis. In vitro studies indicated that uptake of MC by isolated hepatocytes was dramatically reduced as ambient temperature dropped, and some studies presented a hypothesis that differences in core body temperatures in animals result in diverse uptake of MC, as well as different toxic effects. Thus far, however, few in vivo studies have been conducted to investigate the effects of temperature on MC-induced hepatocyte apoptosis in fish, a typical poikilotherm.

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