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Yun Zhang, Zhenzhou Jiang, Yijing Su, Mi Chen, Fu Li, Li Liu, Lixin Sun, Yun Wang, Shuang Zhang and Luyong Zhang Gene expression profiling reveals potential key pathways involved in pyrazinamide-mediated hepatotoxicity in Wistar rats Journal of Applied Toxicology 33

Article first published online: 19 MAR 2012 | DOI: 10.1002/jat.2736

Pyrazinamide (PZA) is an important sterilizing prodrug that shortens the duration of tuberculosis therapy. However, hepatotoxicity has been reported during clinical trials investigating PZA. To determine the hepatotoxic effects of PZA in vivo and to further investigate the underlying cellular mechanism, we profiled the gene expression patterns of PZA-treated rat livers by microarray analysis. Wistar rats of both sexes were orally administered PZA at doses of 0.5, 1.0 and 2.0 g kg−1 for 28 days.

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