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Sandeep Chand Chaudhary, Mohammad Saeed Siddiqui, Mohammad Athar and Mohammad Sarwar Alam Geraniol inhibits murine skin tumorigenesis by modulating COX-2 expression, Ras-ERK1/2 signaling pathway and apoptosis Journal of Applied Toxicology 33

Article first published online: 4 JUL 2012 | DOI: 10.1002/jat.2739

The chemopreventive effect of geraniol was investigated against 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol 13-acetate (TPA)-mediated skin tumorigenesis in female Swiss albino mice. Effects of geraniol on TPA-induced skin edema, hyperplasia, COX-2, oxidative stress, ornithine decarboxylase and [3H] thymidine incorporation were observed. We studied geraniol treatment on incidence and number of tumor and on the expressions of Ras, Raf, ERK1/2, Bcl2 and Bax proteins in skin tumors. Our study concludes that Geraniol alters Ras proliferation pathway and pro-apoptotic state to inhibit DMBA/TPA-mediated skin tumorigenesis.

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