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Waranya Chatuphonprasert and Kanokwan Jarukamjorn Impact of six fruits—banana, guava, mangosteen, pineapple, ripe mango and ripe papaya—on murine hepatic cytochrome P450 activities Journal of Applied Toxicology 32

Version of Record online: 13 APR 2012 | DOI: 10.1002/jat.2740

The effects of six fruits-banana, guava, mangosteen, pineapple, ripe mango, and ripe papaya-on murine CYP1A1, CYP1A2, CYP2E1, and CYP3A11 activities were investigated. Pineapple juice showed the strongest inhibitory effect against P450s in vitro, followed by mangosteen, guava, ripe mango, ripe papaya, and banana. In vivo, the pineapple juice raised ethoxyresorufin O-deethylase, aniline hydroxylase, and erythromycin N-demethylase activities, corresponded to the expression of CYP1A1, CYP2E1, and CYP3A11 mRNAs. These observations supported that these fruits were a feasible cause of food-drug interaction.

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