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O. López-Guarnido, I. Álvarez, F. Gil, L. Rodrigo, H. C. Cataño, A. M. Bermejo, M. J. Tabernero, A. Pla and A. F. Hernández Hair testing for cocaine and metabolites by GC/MS: criteria to quantitatively assess cocaine use Journal of Applied Toxicology 33

Article first published online: 9 MAR 2012 | DOI: 10.1002/jat.2741

A simple, rapid and sensitive GC/MS method has been developed and validated for the sensitive determination of cocaine and its main metabolites cocaethylene and benzoylecgonine in hair. The method is reproducible, robust and precise and fully satisfactory for its application to routine laboratory testing. The procedure was further applied to 40 hair samples from self-reported cocaine users. A new criterion was raised that contributes to minimize false-negative results and allows for a better interpretation of hair testing results.

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