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Yuying Xue, Shanshan Zhang, Yanmei Huang, Ting Zhang, Xiaorun Liu, Yuanyuan Hu, Zhiyong Zhang and Meng Tang Acute toxic effects and gender-related biokinetics of silver nanoparticles following an intravenous injection in mice Journal of Applied Toxicology 32

Article first published online: 23 APR 2012 | DOI: 10.1002/jat.2742

The acute toxic effects and biokinetics of intravenously administered silver nanoparticles (AgNPs) were investigated. AgNPs exerted no obvious acute toxicity when given intravenously in mice at dose levels of 7.5–120 mg kg−1. AgNPs could be distributed extensively to various tissues in the body, and the spleen and liver were the main target organs. Gender-related differences for the biokinetics and distribution were noted, and the elimination half-lives were 15.6 and 29.9 h for male and female mice, respectively.

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