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Eun-Jung Park, Jinkyu Roh, Soo Nam Kim, Younghun Kim, Sang-Bae Han and Jin Tae Hong CCR5 plays an important role in resolving an inflammatory response to single-walled carbon nanotubes Journal of Applied Toxicology 33

Article first published online: 22 MAR 2012 | DOI: 10.1002/jat.2744

Owing to the development of new materials and technology, the pollutants in the environment are becoming more varied and complex over time. In our previous study using ICR mice, we suggested that a single intratracheal instillation of single-walled carbon nanotubes (SWCNTs) induced early lung fibrosis and subchronic tissue damage. In the present study, to investigate the role of CCR5 in inflammatory responses to the uptake of SWCNTs, we compared BAL (Bronchoalveolar lavage) cell composition, cell cycles, cytokines, cell phenotypes, inflammatory response-related proteins, cell surface receptors and histopathology using CCR5 knockout (KO) and wild-type mice.

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