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Polyxeni Zacharaki, Georgia Stephanou and Nikos A. Demopoulos Comparison of the aneugenic properties of nocodazole, paclitaxel and griseofulvin in vitro. Centrosome defects and alterations in protein expression profiles Journal of Applied Toxicology 33

Article first published online: 19 MAR 2012 | DOI: 10.1002/jat.2745

Nocodazole, paclitaxel and the antifungal griseofulvin, with a promising role in cancer treatment, affect microtubule dynamics by different ways. To compare their aneugenic properties we studied: (i) MN induction using CREST analysis, (ii) disturbance of mitotic spindle organization by immunofluorescence, and (iii) alterations in the expression of chromosome segregation regulating protein. We found that the generation of different types of abnormal metaphases dowing to centrosome deffects, as well as the alteration in the expression of proteins regulating chromosome segregation, was dependent on the drug and the cell line treated, reflecting their different effects on microtubule dynamics.

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