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Teresa L. Leavens, Nancy A. Monteiro-Riviere, Alfred O. Inman, James D. Brooks, Steven J. Oldenburg and Jim E. Riviere In vitro biodistribution of silver nanoparticles in isolated perfused porcine skin flaps Journal of Applied Toxicology 32

Article first published online: 4 JUL 2012 | DOI: 10.1002/jat.2750

Nanomaterials increasingly are playing a role in society for uses ranging from biomedicine to microelectronics; however, pharmacokinetic studies, which will be necessary for human health risk assessments, are limited. Currently the most widely used nanoparticle in consumer products is silver (Ag). The objective of the present study was to quantify the local biodistribution of two types of Ag nanoparticles, Ag-citrate and Ag-silica, in the isolated perfused porcine skin flap (IPPSF).

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