Liu Chi-Mou, Tsai Chia-Che, Yu Chia-Yu, Lee Wan-Chi, Ho Chung-Li, Chang Tsui-Jung, Chang Chih-Hsien and Lee Te-Wei Extended acute toxicity study of 188Re-liposome in Rats Journal of Applied Toxicology 33
The present study was performed to assess the toxicity of 188Reliposome in Sprague-Dawley rats. None of the rats died and no clinical sign was observed, and only male rats administered 185 MBq of 188Re-liposome displayed a weight loss. Although the WBC counts of both high-dose and medium-dose groups reduced 7-days postinjection, they recovered to a normal range before termination. There was no difference in urinary analyzes, biochemical parameters and histopathological assessments between the 188Re-liposome-treated and control groups.
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