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Carlos Fernández, Gregoria Carbonell and Mar Babín Effects of individual and a mixture of pharmaceuticals and personal-care products on cytotoxicity, EROD activity and ROS production in a rainbow trout gonadal cell line (RTG-2) Journal of Applied Toxicology 33

Version of Record online: 21 JUN 2012 | DOI: 10.1002/jat.2752

The presence of pharmaceuticals and personal-care products (PPCPs) in aquatic environments is of concern. The aim of the present study was to use the RTG-2 cell line to analyse toxic effects of PPCPs present in wastewater-treatment-plant (WWTPs) effluents and their mixtures. The present study clearly shows that the stress response through which cells mount a homeostatic response to toxicants can be potentially used for an initial, rapid and cost-effective assessment of the complex mixtures of PPCP present in WWTP effluents.

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