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Waranya Chatuphonprasert, Papimon Rermraksakul, Latiporn Udomsuk, Thinnakorn Lao-ong and Kanokwan Jarukamjorn Different profiles of hepatic alkoxyresorufin O-dealkylase activities in small rodents Journal of Applied Toxicology 32

Article first published online: 18 MAY 2012 | DOI: 10.1002/jat.2756

Hepatic ethoxyresorufin O-deethylase (EROD), methoxyresorufin O-demethylase (MROD), pentoxyresorufin O-dealkylase (PROD) and benzyloxyresorufin O-dealkylase (BROD) enzyme activities were determined in ICR, C57BL/6, and DBA/2 mice; Sprague Dawley and Wistar rats; and Dunkin Hartley guinea pigs using β-naphthoflavone, dexamethasone and phenobarbital as inducers. Maximal induction of EROD, MROD, PROD and BROD activities were found in different strains with different inducers. These observations suggested that the choice of experimental animal strain, species and inducer is of critical importance for studies of drug metabolism and interaction.

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