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Noel M. Rysavy, Kristina Maaetoft-Udsen and Helen Turner Dioxins: diagnostic and prognostic challenges arising from complex mechanisms Journal of Applied Toxicology 33

Article first published online: 18 MAY 2012 | DOI: 10.1002/jat.2759

Dioxins are ubiquitous environmental challenges to humans, with a pervasiveness that arises from 200 years of rapid industrialization. Despite their penetrance of the human biota, these compounds are poorly understood in terms of their true physiological potential for harm, and the mechanisms by which they impact cellular and organ level function are only recently becoming clear. Here, we summarize dioxin exposure paradigms and the resulting physiological effects that have been documented in animals and humans.

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