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Georg A. Petroianu, Syed M. Nurulain, Mohamed Shafiullah, Mohamed Y. Hasan, Kamil Kuča and Dietrich E. Lorke Usefulness of administration of non-organophosphate cholinesterase inhibitors before acute exposure to organophosphates: assessment using paraoxon Journal of Applied Toxicology 33

Version of Record online: 19 MAY 2012 | DOI: 10.1002/jat.2760

The reversible AChE-inhibitors pyridostigmine, metoclopramide, tiapride, ranitidine, physostigmine, tacrine, amiloride, methylene blue, 7-methoxytacrine and K-27 were tested as prophylactic agents before exposure to the irreversible AChE-inhibitor paraoxon. Their efficacy in reducing organophosphorus compound-induced mortality was assessed by Cox survival analysis. Best in vivo protection from paraoxon-induced mortality was achieved by physostigmine or the oxime K-27, the most efficacious pretreatment agent not passing the blood brain barrier.

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