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Wen Li and Marion Ehrich Transient alterations of the blood–brain barrier tight junction and receptor potential channel gene expression by chlorpyrifos Journal of Applied Toxicology 33

Version of Record online: 18 MAY 2012 | DOI: 10.1002/jat.2762

We previously demonstrated that exposure to very low concentrations of the organophosphorus insecticide chlorpyrifos (CPF) decreased electrical resistance across the blood–brain barrier (BBB) in vitro, indicating a loss of BBB integrity. This study examined the transient effects of CPF on expression of genes contributing to tight junctions of the BBB. The results suggest that altering gene expression for claudin5, transient receptor potential (canonical) channels (TRPC4), and zona occludens (ZO1) by CPF may directly contribute to BBB disruption, and that the alteration is reversible upon removal of CPF.

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