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Rogelio Recio-Vega, Alejandra Mendez-Henandez, Antonio Padua y Gabriel, Antonio Jacobo-Avila, Arnulfo Portales-Castanedo, Sandra Hernandez-Gonzalez, Martha Patricia Gallegos-Arreola and Guadalupe Ocampo-Gomez Potentially estrogenic polychlorinated biphenyls congeners serum levels and its relation with lung cancer Journal of Applied Toxicology 33

Version of Record online: 22 JUN 2012 | DOI: 10.1002/jat.2763

Occupational and accidental exposure to polychlorinated biphenyls (PCBs) has been associated with an increased risk for lung cancer. Our results shown that, the serum levels of three PCB congeners with potential estrogenic activity were higher in lung cancer patients, which could have dual biological effects on lung tissue, not only inducing cell proliferation in non-neoplastic and neoplastic lung cells via estrogen receptor beta, but also increasing endogenous catechol levels.

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