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Takehiro Suzuki and Keiko Nohara Long-term arsenic exposure induces histone H3 Lys9 dimethylation without altering DNA methylation in the promoter region of p16INK4a and down-regulates its expression in the liver of mice Journal of Applied Toxicology 33

Article first published online: 25 JUN 2012 | DOI: 10.1002/jat.2765

To understand the relationship between arsenic exposure and epigenetic modifications, in the present study we investigated the effects of long-term exposure to arsenic by focusing on the tumor-related gene expression and gene-specific epigenetic modulations in C57Bl/6 mice. The results of this study indicate that long-term arsenic exposure down-regulates p16INK4a without altering DNA methylation in the normal liver, and suggest that its down-regulation is as a result of histone H3K9me2 by G9a recruitment.

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