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Tetsuji Nagao, Nao Kagawa, Yoshiaki Saito and Munekazu Komada Developmental effects of oral exposure to diethylstilbestrol on mouse placenta Journal of Applied Toxicology 33

Version of Record online: 25 JUN 2012 | DOI: 10.1002/jat.2766

Developmental effects of synthetic estrogen, diethylstilbestrol (DES), on mouse placentas were investigated by oral administration during early to mid-stage of gestation. Dose-dependent embryo mortality was observed. Exposure to DES impaired the development of the labyrinth and induced poor rough-surfaced endoplasmic reticulum in trophoblast giant cells. The results suggest that developmental changes induced by DES may be related to interference with nutrition and oxygen exchange between mother and fetus or a decrease in protein synthesis, resulting in fetal mortality.

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