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Tasia Hurd-Brown, Felicia Udoji, Tamara Martin and Margaret M. Whalen Effects of DDT and triclosan on tumor-cell binding capacity and cell-surface protein expression of human natural killer cells Journal of Applied Toxicology 33

Version of Record online: 21 JUN 2012 | DOI: 10.1002/jat.2767

1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) and triclosan (TCS) are found in human blood and decrease the lytic function of human natural killer (NK) cells. This study examined concentrations of DDT and TCS that decrease lytic function for alteration of NK binding to tumor targets. Results indicated that some loss of NK lytic function could be accounted for by loss of binding function and that loss of binding function is accompanied by a loss cell-surface proteins important in binding function.

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