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Nantiga Virgona, Yuko Taki, Shizuo Yamada and Keizo Umegaki Dietary Coleus forskohlii extract generates dose-related hepatotoxicity in mice Journal of Applied Toxicology 33

Version of Record online: 22 JUN 2012 | DOI: 10.1002/jat.2770

The hepatotoxicity effect of Coleus forskohlii root extract (CFE) standardized to 10% forskolin was tested in male ICR mice. Body and organ weights, food intake, plasma marker enzymes for liver damage and liver tissues histology were recorded. Both dietary CFE dose and time dependently affect the observed parameters whereas forskolin, the principle constituent in CFE, is not responsible for such effects.

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