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Makoto Ema, Tadashi Imamura, Hiroshi Suzuki, Norihiro Kobayashi, Masato Naya and Junko Nakanishi Genotoxicity evaluation for single-walled carbon nanotubes in a battery of in vitro and in vivo assays Journal of Applied Toxicology 33

Version of Record online: 5 JUL 2012 | DOI: 10.1002/jat.2772

Single-walled carbon nanotubes (SWCNTs) had no mutagenicity in S. typhimurium TA98, TA100, TA1535, or TA1537, or in E. coli WP2uvrA, in the absence or presence of metabolic activation. SWCNTs did not increase the number of structural or numerical chromosomal aberrations after short-term or continuous exposure. In the micronucleus test using CD-1 mice, SWCNTs did not affect the proportion of immature erythrocytes, the total proportion of erythrocytes, or the number of micronuclei in immature erythrocytes.

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