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Ghada Abdelhamid, Issa E.A. Amara, Anwar Anwar-Mohamed and Ayman O.S. El-Kadi Modulation of aryl hydrocarbon receptor-regulated genes by acute administration of ammonium metavanadate in kidney, lung and heart of C57BL/6 mice Journal of Applied Toxicology 33

Version of Record online: 18 MAY 2012 | DOI: 10.1002/jat.2774

We previously reported that V5+ was able to decrease the TCDD-mediated induction of Cyp1a1 and Nqo1 gene expression levels in Hepa 1c1c7 and HepG2 cells; however, little is known regarding the in vivo effect. Thus, the objective of the current study was to investigate whether or not similar effects would occur at the in vivo level. Therefore, we examined the effect of co-exposure to V5+ and TCDD on the AhR-regulated genes. Our results demonstrated that V5+ modulates TCDD-induced AhR-regulated genes.

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