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Md. Mamunul Haque, Hye-Yeon Im, Ji-Eun Seo, Mahbub Hasan, Kyoungja Woo and Oh-Seung Kwon Acute toxicity and tissue distribution of CdSe/CdS-MPA quantum dots after repeated intraperitoneal injection to mice Journal of Applied Toxicology 33

Article first published online: 25 JUN 2012 | DOI: 10.1002/jat.2775

BALB/c mice were injected every 3 days with various doses of CdSe/CdS-MPA QDs. Body weight of the mice treated with 25 mg/kg QDs was significantly decreased from day 7. The QDs were observed in the liver, spleen, lung, and kidneys, but not in brain, or heart. Significantly higher levels of LDH and NADPH oxidase were found in plasma, liver, and spleen. Histopathological examination did not show any tissue toxicity but IL-6 levels were increased in the plasma, liver, and spleen.

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