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Jacqueline Morais Alves, Carla Carolina Munari, Moacir de Azevedo Bentes Monteiro Neto, Ricardo Andrade Furtado, Juliana Marques Senedese, Jairo Kenupp Bastos and Denise Crispim Tavares In vivo protective effect of Copaifera langsdorffii hydroalcoholic extract on micronuclei induction by doxorubicin Journal of Applied Toxicology 33

Version of Record online: 19 MAY 2012 | DOI: 10.1002/jat.2777

The present study was undertaken to evaluate the genotoxic potential of Copaifera langsdorffii leaf hydroalcoholic extract (CLE) and its influence on the genotoxicity induced by the chemotherapeutic agent doxorubicin (DXR) using the Swiss mouse peripheral blood micronucleus test. The results demonstrated that CLE itself was not genotoxic. In animals treated with CLE and DXR, the number of micronucleus was significantly decreased compared to animals receiving DXR alone.

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