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Kyu-Bong Kim, Ji-Young Yang, Seung Jun Kwack, Hyung Sik Kim, Do Hyun Ryu, Yeon-Joo Kim, Jung Yun Bae, Duck Soo Lim, Seul Min Choi, Mi Jung Kwon, Du Yeon Bang, Seong Kwang Lim, Young Woo Kim, Geum-Sook Hwang and Byung-Mu Lee Potential metabolomic biomarkers for evaluation of adriamycin efficacy using a urinary 1H-NMR spectroscopy Journal of Applied Toxicology 33

Version of Record online: 11 JUL 2012 | DOI: 10.1002/jat.2778

A metabolomics approach using proton nuclear magnetic resonance (NMR) was applied to investigate metabolic alterations following adriamycin (ADR) treatment for gastric adenocarcinoma. After BALB/c-nu/nu mice were implanted with human gastric adenocarcinoma, ADR (1 or 3 mg kg−1 per day) was intraperitoneally administered for 5 days. Urinary endogenous metabolites related to the TCA cycle might be considered as therapeutic targets to potentiate the efficacy of ADR.

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