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Niels Hadrup, Henrik R. Lam, Katrin Loeschner, Alicja Mortensen, Erik H. Larsen and Henrik Frandsen Nanoparticulate silver increases uric acid and allantoin excretion in rats, as identified by metabolomics Journal of Applied Toxicology 32

Article first published online: 18 MAY 2012 | DOI: 10.1002/jat.2779

Metabolomic investigation of rat urine was employed to identify metabolites affected after oral administration of ionic or nanoparticulate silver. By high-performance liquid chromatography time-of-flight mass spectrometry, an increase in uric acid and its degradation product, allantoin, were identified. Verification was done by co-elution with authentic standards. The results suggest that silver affects purine metabolism.

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