E-mail a Wiley Online Library Link

Niels Hadrup, Henrik R. Lam, Katrin Loeschner, Alicja Mortensen, Erik H. Larsen and Henrik Frandsen Nanoparticulate silver increases uric acid and allantoin excretion in rats, as identified by metabolomics Journal of Applied Toxicology 32

Version of Record online: 18 MAY 2012 | DOI: 10.1002/jat.2779

Metabolomic investigation of rat urine was employed to identify metabolites affected after oral administration of ionic or nanoparticulate silver. By high-performance liquid chromatography time-of-flight mass spectrometry, an increase in uric acid and its degradation product, allantoin, were identified. Verification was done by co-elution with authentic standards. The results suggest that silver affects purine metabolism.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field