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Robert S. Woodruff, Yan Li, Jian Yan, Michelle Bishop, M. Yvonne Jones, Fumiya Watanabe, Alexandru S. Biris, Penelope Rice, Tong Zhou and Tao Chen Genotoxicity evaluation of titanium dioxide nanoparticles using the Ames test and Comet assay Journal of Applied Toxicology 32

Version of Record online: 29 JUN 2012 | DOI: 10.1002/jat.2781

The genotoxicity of 10 nm anatase titanium dioxide nanoparticles was assessed using the Ames test and Comet assay. The nanoparticles were neither mutagenic in the Ames test nor genotoxic in the Comet assay. The results also suggest that the Ames test may not be suitable to measure the mutagenicity of the nanoparticles because the bacterial cells cannot take up the nanoparticles.

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