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Laura Musacchio Vargas, Melina Bucco Soares, Aryele Pinto Izaguirry, Diogo Seibert Lüdtke, Hugo C. Braga, Lucielli Savegnago, Suzi Wollenhaupt, Daniela dos Santos Brum, Fábio Gallas Leivas and Francielli Weber Santos Cadmium inhibits the ovary δ-aminolevulinate dehydratase activity in vitro and ex vivo: protective role of seleno-furanoside Journal of Applied Toxicology 33

Article first published online: 4 JUL 2012 | DOI: 10.1002/jat.2783

The cadmium (Cd) effect on ovary δ-aminolevulinate dehydratase (δ-ALA-D) activity was investigated in vitro and ex vivo. Cadmium inhibited cow ovary δ-ALA-D activity and seleno-furanoside did not reverse the Cd toxicity in vitro. Acute Cd exposure caused a significant inhibition on ovary δ-ALA-D activity in mice and seleno-furanoside was able in restoring enzyme activity. Ovarian δ-ALA-D activity is inhibited by Cd both in vitro and ex vivo and the seleno-furanoside therapy was effective after Cd acute exposure in mice.

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