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Zhenxing Mao, Wei Xia, Jun Wang, Tian Chen, Qianqian Zeng, Bing Xu, Weiyong Li, Xi Chen and Shunqing Xu Perfluorooctane sulfonate induces apoptosis in lung cancer A549 cells through reactive oxygen species-mediated mitochondrion-dependent pathway Journal of Applied Toxicology 33

Version of Record online: 13 SEP 2012 | DOI: 10.1002/jat.2785

Perfluorooctane sulfonate (PFOS) is a widespread environmental contaminant that is detected in the lung of mammalian. The mechanisms underlying PFOS-induced lung cytotoxicity remain unclear. We treated human lung cancer A549 cells with PFOS and the cellular apoptosis, mitochondrial membrane potential, intracellular ROS were determined. PFOS induced a dose-dependent increase in A549 cells toxicity via apoptosis pathway with obvious oxidative stress. N-acetylcysteine (NAC) as an antioxidant can block PFOS-induced ROS generation, mitochondrial membrane potential loss and cell apoptosis.

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