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Sairam Bellum, Kerry A. Thuett, Bhupinder Bawa and Louise C. Abbott The effect of methylmercury exposure on behavior and cerebellar granule cell physiology in aged mice Journal of Applied Toxicology 33

Version of Record online: 10 AUG 2012 | DOI: 10.1002/jat.2786

16-20 month old C57BL/6 mice were exposed orally to 5.0 mg methylmercury per kg body weight. Methylmercury-treated aged mice performed significantly worse in open field, foot print analysis and a vertical pole test. Isolated cerebellar granule cells from methylmercury-treated aged mice exhibited higher reactive oxygen species levels and reduced mitochondrial membrane potentials. Aged mice exposed to methylmercury exhibited no greater impairment compared to young adult mice exposed to the same dose, as reported in earlier studies from this lab.

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