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Tamer Said Abdelkader, Seo-Na Chang, Tae-Hyun Kim, Juha Song, Dong Su Kim and Jae-Hak Park Exposure time to caffeine affects heartbeat and cell damage-related gene expression of zebrafish Danio rerio embryos at early developmental stages Journal of Applied Toxicology 33

Version of Record online: 9 AUG 2012 | DOI: 10.1002/jat.2787

Caffeine has various biological effects. Effect of (100 μM) caffeine on heartbeat, survival and expression of cell damage-related genes were studied. Hatching decreased significantly in caffeine treatment at 60 and 72 hpf. Heartbeat increased significantly at 72 and 96 hpf. Significant up-regulation was found in all tested genes, Bax/Bcl2 ratio, and significant down-regulation in Bcl2. Caffeine exposure, increase heartbeats, stimulates oxidative stress and may trigger apoptosis via a mitochondrial-dependent pathway. Use of caffeine harm the human fetus by affecting the cell-damage related genes.

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