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Jonathan Arauz, Marina Galicia- Moreno, Pedro Cortés-Reynosa, Eduardo Pérez Salazar and Pablo Muriel Coffee attenuates fibrosis by decreasing the expression of TGF-β and CTGF in a murine model of liver damage Journal of Applied Toxicology 33

Version of Record online: 17 AUG 2012 | DOI: 10.1002/jat.2788

Cirrhosis was induced by chronic TAA administration and the effects of co-administration of conventional coffee or decaffeinated coffee respectively for 8 weeks were evaluated. TAA administration elevated serum alkaline phosphatase, γ-glutamyl transpeptidase and alanine aminotransferase, liver lipid peroxidation and collagen content. Additionally increased levels of a number of proteins were detected including transforming growth factor-β, connective tissue growth factor and alpha-smooth muscle actin, and matrix metalloproteinase-2, 9 and 13. Coffee suppressed most of the changes produced by TAA.

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