E-mail

E-mail a Wiley Online Library Link

Anna Rymuszka Microcystin-LR induces cytotoxicity and affects carp immune cells by impairment of their phagocytosis and the organization of the cytoskeleton Journal of Applied Toxicology 33

Article first published online: 25 SEP 2012 | DOI: 10.1002/jat.2791

The present study investigated the in vitro toxic microcystin-LR (MC-LR) effects on immune cells isolated from the blood of carp. Moreover, the effect of the toxin on the phagocytic activity of leukocytes and on actin and tubulin re-organization in phagocytic cells was studied. Incubation of the cells with MC-LR inhibited phagocytosis without affecting apoptosis or glutathione levels. The toxin induced a significant re-organization of the actin cytoskeleton in phagocytes. These results suggest that fish phagocytes and lymphocytes are targets for MC-LR.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

Choose captcha format: Image or Audio. Click here if you need help.

SEARCH