Anna Rymuszka Microcystin-LR induces cytotoxicity and affects carp immune cells by impairment of their phagocytosis and the organization of the cytoskeleton Journal of Applied Toxicology 33
The present study investigated the in vitro toxic microcystin-LR (MC-LR) effects on immune cells isolated from the blood of carp. Moreover, the effect of the toxin on the phagocytic activity of leukocytes and on actin and tubulin re-organization in phagocytic cells was studied. Incubation of the cells with MC-LR inhibited phagocytosis without affecting apoptosis or glutathione levels. The toxin induced a significant re-organization of the actin cytoskeleton in phagocytes. These results suggest that fish phagocytes and lymphocytes are targets for MC-LR.
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