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Anna Rymuszka Microcystin-LR induces cytotoxicity and affects carp immune cells by impairment of their phagocytosis and the organization of the cytoskeleton Journal of Applied Toxicology 33

Version of Record online: 25 SEP 2012 | DOI: 10.1002/jat.2791

The present study investigated the in vitro toxic microcystin-LR (MC-LR) effects on immune cells isolated from the blood of carp. Moreover, the effect of the toxin on the phagocytic activity of leukocytes and on actin and tubulin re-organization in phagocytic cells was studied. Incubation of the cells with MC-LR inhibited phagocytosis without affecting apoptosis or glutathione levels. The toxin induced a significant re-organization of the actin cytoskeleton in phagocytes. These results suggest that fish phagocytes and lymphocytes are targets for MC-LR.

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