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Anne-Pascale Luzy, Nicolas Orsini, Jean-Michel Linget and Guy Bouvier Evaluation of the GADD45α-GFP GreenScreen HC assay for rapid and reliable in vitro early genotoxicity screening Journal of Applied Toxicology 33

Version of Record online: 13 JUL 2012 | DOI: 10.1002/jat.2793

Proprietary and reference molecules were used to compare the GADD45α-GFP ‘GreenScreen HC’ assay (GS) with in vitro screening tests. The GS renders the SOS-ChromoTest obsolete, confirms all results of the mini-Ames test and shows concordance of 82% with the micronucleus assay. The GS detected accurately catecholamines, carbendazim, tetracycline antibiotics and carbaryl. The GS produced negative results for metronidazole, dexamethasone, for rosiglitazone and for clindamycin and neomycin. The GS appears reproducible, robust, specific and sensitive test for genotoxicity screening.

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